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17 , E1631 (2016)

The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

For many people, it comes on suddenly, overnight, or within the first minutes of waking up, with no apparent cause

Method development and validation

Consequently, this may lead to a gradual lightening of the skin tone