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Indeed, silencing -syn has led to neuroprotection in vitro upon 1-methyl-4-phenylpyridinium (MPP+) insult (Fountaine and Wade-Martins, 2007)

It is unclear why an ancestor to all extant metazoans eventually discarded its -type TrxRs, which presumably functioned adequately in its ancestors and continues to do so for nearly all contemporary non-metazoans within all biological kingdoms (Fig