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In general, according to the results of various studies, it seems that cyclic ACPs have better anti-cancer and less toxicity than other ACPs

10.1016/j.redox.2021.101928 67 HongT.LeiG.ChenX.LiH.ZhangX.WuN.et al (2021c)

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In order to reduce background cord formation and increase responsiveness to exogenously added angiogenic growth factors, a basal media (BM) was developed which lacks serum and any additional growth factors