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VitD deficiency is linked to diminished bone mineralization and heightened cortical bone loss, which exacerbates the development and progression of OP in the elderly, hence increasing bone fragility ( 2 ) and cholecalciferol (vitamin D 3 ), both of which can be acquired from various diets, though fortified goods and supplements are significant sources ( Lactobacillus rhamnosus GG (LGG), affect the absorption of cholecalciferol by modulating the expression of VitD transporters in IECs

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Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-I (72)

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doi:10.1016/0076-6879(95)51107-5