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Immunol., 178, 23442351 20

[1] This net flow through the semipermeable membrane produces a pressure called osmotic pressure , denoted as , which can be defined as the force that must be applied to prevent the movement of solvent molecules through a semipermeable membrane

While such an arrangement could be achieved by small disulfides such as HEDS, bulky protein substrates might cause significant deviations from this reaction geometry (Fig