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You should contact your GP or NHS 111 if you experience: Persistent diarrhoea lasting more than 7 days in otherwise healthy adults Blood or mucus in stools , which may indicate inflammatory bowel disease or infection Severe abdominal pain or cramping that is worsening or different from previous digestive symptoms Unexplained weight loss alongside bowel changes Signs of allergic reaction , including rash, itching, swelling, or difficulty breathing (call 999 or go to A&E for severe reactions) Neurological symptoms such as numbness, tingling, balance problems, or memory difficulties, which may indicate B12 deficiency is not being adequately treated Seek help sooner if you have red flag symptoms, are pregnant, immunosuppressed, elderly, or have significant underlying health conditions

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Prior studies have used the cell cycle proteins p16, p21, p53 and Rb to differentiate between dividing and non-dividing cells, but the non-dividing cells can include senescent cells and quiescent cells 36

The auxiliary examination methods and results are as follows

Estradiol (intramuscular route)