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This observation is in line with the study objective, i.e., to confirm the biochemical synergy for the combination treatment reported in the literature

Thiamine is especially important for alcohol and drug detox, because chronic alcohol use causes thiamine deficiency, which leads to Wernickes encephalopathy and Korsakoff syndrome, as studied by Martin PR, Singleton CK, Hiller-Sturmhfel S

Finally, to examine the time required for each phase in more detail, the completed studies registered as phase I, phase II, or phase III were extracted, and we analyzed them by the time required for individual studies using the completion year, instead of the start year

10.1016/j.jenvman.2019.109557 J

Specific compounds, including naturally occurring polyphenols, can function as hypermethylation agents, effectively counteracting the epigenetic suppression of tumor suppressor genes