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In studies investigating the extension of gestational weeks in pregnant females with early-onset preeclampsia treated with metformin, metformin (1,0003,000 mg/d) significantly prolonged the expected time for treatment, and shortened the length of stay in the neonatal intensive care unit

10.1371/journal.pone.0100525 Pubmed Abstract CrossRef Google Scholar View reference in article 31

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This ability to specifically protect thyroid receptor function from being shut down because of inflammatory processes increases RXR/TR heterodimerization and allows the RXR/TR heterodimer to target gene expression