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Notably, the decreased cortisol did not associate with a compensatory increase in ACTH levels, suggesting that the hypothalamicpituitary axis response to regulate cortisol may be inappropriately blunted

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The transcript quantity was measured on an ABI Prism 7500 Fast (Applied Biosystems, Paisley, UK) using the housekeeping gene rla-1 (acidic ribosomal subunit protein P1) for normalization purposes (Swain et al