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Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

doi: 10.1016/j.cell.2016.08.072 9 KrogsgaardMDavisMM

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For researchers running dose-escalation studies or comparing multiple dosing regimens simultaneously, smaller vial sizes (5mg/5mg or 6mg/6mg) offer flexibilityeach subject cohort can be assigned a dedicated vial, minimizing cross-contamination risk and simplifying dose tracking

These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma