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Considering the fact that tumour microenvironment stresses are strong inducers of the endoplasmic reticulum stress (Murakami et al, 2007), the FASN inhibitors could show selective and enhanced cytotoxicity to cancer cells under the tumour microenvironment conditions

doi: 10.31887/dcns.2009.11.3/mbelanger, 31

Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway

If offering peptides outside approved indications, clinicians should present use as experimental, disclose regulatory status and paucity of clinical studies, describe known and unknown risks, and outline standard treatment alternative (e.g