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Am J Physiol Cell Physiol 287(4):C817C833

These range from the low permeability of the cell wall, to altered EPSPS binding sites, and active removal from the cell (Staub et al

168 The consensus among experts is that due to the deleterious effect that elevated homocysteine levels has on both Parkinson's itself and L-DOPA therapy, supplementation with folate, B6, and B12 is warranted