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However, only pimitespib, an oral inhibitor developed by Taiho Pharmaceutical, was approved in Japan in 2022 for gastrointestinal stromal tumors, and it is currently the focus of a phase I study for the treatment of solid tumors in the EU and USA [7, 8]

495-497 However, even after decades of neuropsychiatric research, the monoamine hypothesis of depression remains supported only by an inconsistent and increasingly tenuous evidence base

Given that oxidative stress and inflammatory damage peak early in critical illness and trauma, delayed selenium administration may limit its protective effects

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