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These antioxidants, in combination with Glutathione, help protect the skin from environmental damage, slow down the aging process, and promote skin rejuvenation

Mechanistically, DAMPs interact with toll-like receptors (TLRs) and purinergic receptors on Kupffer cells, resulting in the secretion of pro-inflammatory mediators such as IL-6, IL-18, IFN-, TNF-, and Fas ligands, which further promote macrophage proliferation [54]

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However, there are insufficient studies on curcumin cooperating with the sestrin family to inhibit tumors, and the mechanism is still unclear

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