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Conformational changes are generally small, involve the protein backbone, and are often accompanied by a local increase in protein disorder (Mallis et al., 2000

Hg 2+ reacts with thiol groups (SH), thus depleting intracellu- lar thiols, especially glutathione and causing oxidative stress or predisposing cells to it [8]

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Another study demonstrated in mouse embryonic fibroblasts that TanIIA inhibits myofibroblast activation through restoring redox homeostasis by activating Nrf2 and suppressing Nox4