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C.Schlotzer-SchrehardtU.et al (2015)

AOD-9604 would lose activity

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease

Combination therapy group received PEG-IFN-2b for 12 weeks followed by TDF add-on for 36 weeks, TDF monotherapy group received TDF for 48 weeks and control group were followed-up without any antiviral treatment (Figure 1A)

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