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edition V

Long-chain-fatty-acidCoA ligase 4 (ACSL4) incorporates PUFAs into lipid membranes and increases the susceptibility of tumor cells to ferroptosis [6]

[DOI] [PubMed] [Google Scholar] 135.Filipovic M.R., Zivanovic J., Alvarez B., Banerjee R

Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178