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Evidence Comparison# What Has Changed Since 2025# Several developments have shifted the anti-aging peptide landscape in 2025-2026: Klotho primate data -- The 2023 Nature Aging publication showing cognitive enhancement in aged nonhuman primates moved klotho from a theoretical longevity target to a near-translational candidate, with gene therapy approaches now in development

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A statement to confirm that all methods were carried out in accordance with relevant guidelines and regulations

The Pinealon benefits guide explores the broader neuroprotective profile, and the bioregulator peptides guide covers the Khavinson research framework that produced Pinealon and related compounds