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3d,e, Extended Data Fig

Elevated extracellular glutamate levels contribute to the tonic activation of mGluR2 and mGluR3, predominantly located presynaptically [69]

M.TuY.et al (2016)

For ac , n = 3 independent experiments

For instance, it has been demonstrated that NR supplementation is safe up to 3000 mg daily, with readouts reported for NAD + levels, mitochondrial function, and clinical phenotypes measured in several trials 246,310,311,312,313