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(R)-Methotrexate-d 3 (R)-Methotrexate-d 3 is the deuterium labeled (R)-Methotrexate

the present invention encompasses any racemic, optically-active, diastereomeric, polymorphic, or stereoisomeric form, or mixtures thereof, of a compound of the invention, which possess the useful properties described herein, it being well known in the art how to prepare optically active forms (for example, by resolution of the racemic form by recrystallization techniques, by synthesis from optically-active starting materials, by chiral synthesis, or by chromatographic separation using a chiral stationary phase)

For the purpose of this discussion, we have defined muscle fatigue as an exercise-induced decrease in muscle force generation (130, 408)

Although many of these molecules have demonstrated good preclinical results, only a few have actually been translated in ongoing clinical trials, probably due to increased cytotoxicity events

10.1021/acsptsci.2c00203 244 SandhirR.MahajanN.MehrotraA.AggarwalA.SunkariaA