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The Gut Link: Malabsorption (common in those over 50 or on PPIs) is the leading cause of B12 deficiency and subsequent bone loss

Standard Hypothyroidism: If you have a standard underactive thyroid caused by an autoimmune condition (Hashimoto's) or thyroid surgery/radioiodine for overactivity, you do not fall into these high-risk categories

Severe chronic conditions may need 12+ weeks plus ongoing maintenance

The reason is that the source of these compounds is derived from living organisms through enzymatic polymerization, forming high molecular weight macromolecules