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Zitoun, C

FIGURE 11 Ferroptosis is characterized by the iron-dependent accumulation of lipid ROS and is morphologically and mechanistically distinct from other programmed cell death pathways (Dixon and Stockwell, 2014

46 In addition, isolated guinea pig trachea exposed to 2.5, 5, 7.5, and 10 mg/mL macerated aqueous Jamun leaf extract showed an attenuated potassium chloride-induced contraction and caused tracheal relaxation concentration dependently

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At the mechanistic level, intracellular iron availability is coordinated by HIF signaling together with iron regulatory proteins (IRPs) (70), linking oxygen sensing to epithelial redox vulnerability