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XX wieku w badaniach zespou Predraga Sikia i wsppracownikw z Uniwersytetu w Zagrzebiu (Siki et al., Journal of Physiology , 1993)

6 Obesity-related hypothalamic inflammation and proinflammatory cytokine production can lead to suppression of leptin signaling and failure to feel the sensation of being full, known as leptin resistance

Moreover, our structures reveal a distinct binding mode of inverse agonists with receptors, define cavities for ligand recognition, and decipher the action mechanism of inverse agonists and agonists for ghrelin receptors