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Findings: Coformulation of metformin and glutathione was associated with improvements in sperm count, motility, and morphology

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Future studies should aim to define its optimal therapeutic time window and design biomarker- and pathology-related clinical endpoints to validate its disease-modifying potential

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In T2DM, upregulation of AMPK activity has been shown to inhibit mTOR, reducing autophagic vacuoles and potentially improving cell function