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Description

Li et al., 2008

doi: 10.4103/sjamf.sjamf_50_19 341

Copper overload can lead to excessive ROS accumulation, enhance myeloperoxidase activity and activate the NF-B signaling pathway, promoting the release of pro-inflammatory cytokines (such as IL-1 and TNF-) while inhibiting anti-inflammatory cytokines, resulting in a chronic inflammatory state (132,133)