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One of the key elements causing the BRB to change is VEGF

Gastroenterology 149(1):110118 Zhu L, Gu P, Shen H (2019) Gallic acid improved inflammation via NF-B pathway in TNBS-induced ulcerative colitis

GSH levels and the GSH/GSSG ratio are important indicators of oxidative stress and redox balance, with decreased GSH levels and increased GSSG levels being associated with neurological aging

10.1002/cncr.20605 133 LiY.SunW.HanN.ZouY.YinD

Encouragingly, a phase II study in astrocytoma patients confirmed the safety and efficacy of combining TVB-2640 with bevacizumab, successfully meeting its primary endpoint [212]