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As the central hub of cellular energy production, mitochondrial damage not only may lead to a decline in ATP synthesis but also may disrupt immune activation and neuronal function through metabolic signaling

Recently, Wald et al (1998) estimated the risk of ischemic heart disease (angina pectoris or myocardial infarction) from eight retrospective studies and from their own positive prospective study, the British United Provident Association study, as a function of homocysteine level

More and more evidence shows a close relationship between ERS and autophagy, with autophagy being an important downstream event of ERS [91]

Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial

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