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First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5

2009: A melanoma was surgically removed from her calf and a groin sentinel lymph node was clear

However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate (Cui et al., 2013)

Despite their indispensability, amino acids are often scarce within the tumor microenvironment 46 , driving tumors to enable strategies to import and synthesize them 712

Results Creation of a yeast model for 5-oxoproline accumulation To study the effect of intracellular accumulation of 5-OP in yeast cells we needed a system that could result in accumulation of a high amount of intracellular 5-OP