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Despite being effective in blocking the conversion of DOPA to melanin, hydroquinone monotherapy has moderate effectiveness on hyperpigmentation [76, 77] and is responsible for numerous side effects such as mild erythema, burning sensation, dryness, pruritus, and scaling, making it prohibited for use in cosmetics in a majority of countries [77,78,79,80]

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Angiology 1995;46(8):705-713

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