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TABLE 2 Summary of DDS treatment methods for hyperuricemia

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LRRK2 is recruited to the mitochondrial outer membrane by mitochondria-anchored Rab29 (also called Rab7L1) ( RAB29 is also a risk gene of PD identified in PARK16 loci from several GWASs (Satake et al., 2009), and in addition to mitochondria Rab29 is also distributed at trans-Golgi network, lysosomes, and autophagic vesicles to regulate membrane trafficking, lysosome homeostasis, and axonal transport of autophagosomes with LRRK2 (Wauters et al., 2020)

Hjazi and colleagues (Hjazi et al., 2024) further advanced this therapeutic approach by combining MenSC-Exos with hyperbaric oxygen therapy (HBOT) in a model of traumatic SCI (TSCI)