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The patient, guardians, and researchers were not blinded to treatment selection

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The metE DNA vaccine primarily induced a Th1-biased immune response of CD4+ T cells producing IFN-, TNF-, and IL-2, but failed to elicit a strong antibody response, with no statistically significant increase in any of the measured immunoglobulin subclasses compared to nave group ( Figures 6AC )

It coincides with other metabolic disorders such as obesity, insulin resistance, diabetes, hypertension, and cardiovascular disease

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