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De Tullio et al., 2003

Exocyclic olefinic maleimides: Synthesis and application for stable and thiol-selective bioconjugation

The release of proteases, including matrix metalloproteinases (MMPs), tissue proteases and neutrophil elastase, degrades the extracellular matrix and alveolar elastin, leading to localized and generalized alveolar emphysema (25)