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This hypothesis was confirmed in a recent study that the inflammation inhibitor IL-37 boosted MSU phagocytosis by macrophages, lowered the transcription of pyroptosis-associated proteins, and diminished the release of inflammatory cytokines post-phagocytosis, thereby mitigating the inflammatory response in gout (54)

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Molecular graphics were generated using Pymol 62 and UCSF ChimeraX 63

Gastrointestinal manifestations Oral cavity Common oral manifestations of PA include atrophic glossitis, angular chelitis, and recurrent oral ulcerations

Peripheral neuropathy affects millions of people and is a growing concern, particularly amongst individuals living with diabetes and those who have long term nutritional absorption issues