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Funding This work was supported by the Department of Science and Technology, Government of India under the scheme of Women Scientist [WOS-B /DST/WOS-B/HN-25/2021-RENU (G)]

This study clarified the potential mechanism of PFOS-mediated RTC apoptosis and provided a new strategy for using l-Carnitine to prevent and treat PFOS-induced RTC apoptosis

For this reason, Health Canada does not accede the use of l-carnitine and acetyl-l-carnitine in food supplements until additional information becomes available [96]

In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis