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As part of the PDH complex, PDHB participates in the decarboxylation of pyruvate and is involved in the glycolytic pathway, thereby modulating cellular energy metabolism

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Importantly, glucose metabolism and insulin sensitivity were either unchanged or slightly improved, contrasting with the diabetogenic effects of growth hormone

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Further in-depth pharmacokinetic studies on humans and toxicology research, the mechanism of combination therapy, and research on new CHE-based biomaterials for reducing drug toxicity and structurally optimized analogs are required to enhance the efficacy and safety of CHE, and more clinical studies are required in the future to validate preclinical studies of CHE as an antitumor strategy