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Ming Zhang, Wenjuan Han, Sanjue Hu, and Hui Xu*

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Our aim was to examine if we, based on the collected information, could gain more insight into how chemicals induce these effects and use the information to elaborate more robust modes of action or Adverse Outcome Pathway frameworks ( Compounds With a Clear Dose Related Effect on Both NR and AGD Flutamide, vinclozolin and procymidone all have AR antagonistic activity, and all three show very marked anti-androgenic effects in vivo