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Sultana R, Poon HF, Cai J, Pierce WM, Merchant M, Klein JB, Markesbery WR, Butterfield DA

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In contrast to therapeutic targeting of antioxidant pathways, we have pursued a complementary strategy for ferroptosis induction based on enhancing the production of lipid hydroperoxides

The nanosystem only enabled the enhancement of siG-Cy5 accumulation in the superficial layer (0-40 m) of the untreated tumors due to its limited access to the deep tumor (Fig