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Acetylcarnitine modulation of the morphology of rat hippocampal synapses Anal Quant Cytol Histol 1996

Furthermore, through epigenetic mechanismsspecifically the acetylation of histonesALCAR can upregulate specific receptors like metabotropic glutamate 2 (mGlu2), a pathway that stimulates neurogenesis, enhances synaptic plasticity, and has been strongly tied to the compound's clinical antidepressant effects

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The intestinal absorption of carnitine, as well as its renal reabsorption, is primarily mediated by the plasma membrane organic cation transporter novel 2 (OCTN2 SLC22A5) that, among the carnitine-handling transporters, shows the highest affinity toward carnitine

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