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The brain tissue of PD patients is typically characterized by the death of dopaminergic, neuromelanin-containing neurons in the area of locus coeruleus and substantia nigra

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However, this concept must be modified, because it is now known that certain conjugation reactions (acyl glucuronidation of nonsteroidal anti-inflammatory drugs, O -sulfation of N -hydroxyacetylaminofluorene, and N -acetylation of isoniazid) may lead to the formation of reactive species responsible for the toxicity of the drugs

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Precautions Children and pregnant women should not eat