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Glossary AD Alzheimers Disease AKT Protein kinase B APP Amyloid precursor protein ATP Adenosine triphosphate BDNF Brain-derived neurotrophic factor CREB cAMP response element-binding protein CTX Cortex C/EBP CCAAT-enhancer-binding proteins EA Erinacine A EB Erinacine B EC Erinacine C EF Erinacine F EL Erinacine L ERK1/2 Extracellular signal-regulated kinase 1/2 ES Erinacine S EZ1 Erinacine Z1 EZ2 Erinacine Z2 GLT-1 Glutamate transporter 1 GSK-3 Glycogen synthase kinase-3 beta HE Hericium erinaceus HEM Hericium erinaceus mycelia HEME Hericium erinaceus mycelia extracts Hip Hippocampus H 2 O 2 Hydrogen peroxide HO-1 Heme oxygenase-1 ICR Institute of Cancer Research IFN- Interferon-gamma IL-6 Interleukin-6 iNOS Inducible nitric oxide synthase JNK c-Jun N-terminal kinase LIMK2 LIM domain kinase 2 LPS Lipopolysaccharide MAPK Mitogen-activated protein kinase MPP+ 1-Methyl-4-phenylpyridinium MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine NF-B Nuclear factor kappa-light-chain-enhancer of activated B cells NGF Nerve growth factor Nrf2 Nuclear factor erythroid 2-related factor 2 NT-3 Neurotrophin-3 OPC Oligodendrocytes progenitor cell PAK1 p21-activated kinase 1 PCR Polymerase chain reaction PI3K Phosphoinositide 3-kinase pCREB Phosphorylated CREB PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analyses PS1 Presenilin 1 SAMP8 Senescence Accelerated Mouse-Prone 8 SCA3 Spinocerebellar ataxia type 3 SD Sprague Dawley SOD1 Superoxide dismutase 1 TBI Traumatic brain injury tBT Tert-butyl hydroperoxide tHI Transient hypoxia-ischemia TNF - Tumor necrosis factor-alpha Trk Tyrosine receptor kinase TrkA Tyrosine receptor kinase A TrkB Tyrosine receptor kinase B Trx Thioredoxin TrxR Thioredoxin reductase References 1 AggarwalN

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We also observed that PC cells with upregulating expression of SLC7A11 at the PM level induced by VRK2 display decreased incidence of ferroptosis, which accounts for why PC cells with VRK2 high expression are insensitive to GSH inhibition alone