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Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

10.1002/emmm.201200245 [DOI] [PMC free article] [PubMed] [Google Scholar] Bischoff-Ferrari HA, Gngler S, Wieczorek M, Belsky DW, Ryan J, Kressig RW, Sthelin HB, Theiler R, Dawson-Hughes B, Rizzoli R, Vellas B, Rouch L, Guyonnet S, Egli A, Orav EJ, Willett W, Horvath S (2025) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial

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It is important to note that references to these compounds in 'anti-ageing' contexts reflect marketing claims rather than established clinical benefit