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Transl Neurodeg 6:135 Malik BR, Maddison DC, Smith GA, Peters OM (2019) Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)

The mean ARA:DHA ratio found for most countries (Australia, Canada, UK, Mexico, China, Spain) was 1.6:1 whereas the ratio was lower for Japan (0.5:1) and higher for China (2:1 to 3:1) (35, 36, 48) and USA (3.2:1) (44) (Figure 4)

While adequate folate intake appears protective before malignant change occurs, excessive folic acid exposure, particularly in susceptible individuals with reduced DHFR activity, may not always be desirable

Unknown Mechanisms of Behavioral Changes The precise identification of the impaired neuronal network and the molecular mechanisms underlying behavioral and emotional changes, particularly behavioral disinhibition in Lurcher mice, are still unknown