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Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

doi: 10.1016/j.jhep.2022.12.014

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804 Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis