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Kanski J, Aksenova M, Stoyanova A, Butterfield DA

Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis

As diabetics often have combined disorders that involve multiple hormones, and as the primary cause of diabetes is impaired insulin production or insulin resistance, all associated factors are grouped together under the term insulin protein superfamily