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We simply do not know, and these are not trivial questions: good science is about minimizing the impact of stray variables and zeroing in on the specific question we are asking

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Therefore, improvement of NOS dysfunction by BH 4 supplementation with sepiapterin probably involves both reversal of NOS uncoupling by replenishing BH 4 , and protection of the oxidase site by scavenging of peroxynitrite due to the antioxidant properties of BH 4

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In keeping with this trend, serum IGF1 has been reported to increase in ND individuals after the initiation of insulin treatment [38]