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[,,,] The inflammatory mediators further return to the lung through the systemic circulation, accompanied with lymph fluid from the gastrointestinal tract, and consequently, the lung resident macrophages are activated and participate in systemic inflammatory reaction, conversely, the inflammatory reaction in the lung feeds back to the gut and liver through blood circulation, thus forming the gut-liver-lung axis [] [Figure 6]

HNF4alpha regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer