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Acknowledgments This work was supported by operating grants from the Natural Sciences and Engineering Research Council of Canada (NSERC

CIRI: Cerebral ischemia and reperfusion injury PGC1: Peroxisome proliferator-activated receptor-gamma coactivator MS: Multiple sclerosis BBB: Blood-brain barrier DHLA: Dihydrolipoic acid References Park S, Karunakaran U, Ho Jeoung N, Jeon JH, Lee IK (2014) Physiological effect and therapeutic application of alpha lipoic acid

Hence, the purpose of this narrative review is to analyze the literature and provide evidence supporting the importance of endothelial dysfunction in COPD