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While research is still evolving, the compound has gained attention because of its potential connection to biological aging, sleep regulation, and cellular repair pathways

In sepsis-induced acute kidney injury, spermidine improves renal outcomes by acting on macrophages, where it suppresses NLRP3 inflammasome activation and IL-1 production, preserves mitochondrial respiration, and relies on eIF5A hypusination to regulate macrophage function 118

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Two of these transcription factors, NF-B and AP-1, are involved in inflammation, cellular proliferation, and apoptosis (Silva-Adaya et al., 2014