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REDEFINE 2 (combination, with type 2 diabetes) In adults with type 2 diabetes, the combination achieved 13.7% weight reduction versus 3.4% for placebo

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The treatment landscape for CKM changed dramatically when agents from several medication classes, originally developed as glucose-lowering therapies, were recognized to reduce the risk of multiple components of CKM syndrome

Also at this level, the astrocyte-neuron metabolic dialogue reveals its importance, since astrocytes, which are endowed with an intrinsically competent antioxidant system, convey some of this antioxidant potential to neurons (29)