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Moreover, although targeting glutamine metabolism inhibits the entry of carbon catabolized by glutamine into the TCA cycle, it was found that the glycolytic process is not altered by targeting glutamine metabolism in AML cells, implying that the products required for the TCA cycle are not affected [16]

DOI: 10.3389/fphar.2014.00196

Accordingly, analysis of general health parameters such as body weight and temperature as well as weight of different organs, revealed similar age-related changes in xCT +/+ and xCT / mice (Supplementary Fig

Together, these findings highlight the pivotal role of nuclear zinc regulation in maintaining genomic integrity, transcriptional fidelity and healthy cell-cycle progression

Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model